$65.00 - $125.00
mNIS2 (Sodium Iodide Symporter)
In its function as a reporter, the Sodium Iodide Symporter (NIS) is a non-invasive, precise imaging reporter gene with many applications in both the medical and biotechnology field. It enables researchers to track cells in vivo via nuclear imaging due to its ability to drive the uptake of radioactive iodine into cells as well as several other radiotracers at the site of transgene expression.
NIS is the most common human reporter gene in use, and NIS imaging has several key advantages: it produces high-resolution 3D images, it can track anatomical gene therapy delivery with a high degree of precision, it is translational from small to large animals as well as humans, and it is non-immunogenic when species-specific and therefore usable in longitudinal imaging studies. Because NIS can be used for generating transgenic animals, generating GM-Cells, and being delivered directly to animals and/or humans, it’s essential that the proper gene from the appropriate species be used so there is no immune rejection. Therefore, the pOSP-CCRV-1 includes both mNIS2 and hNIS2.