6. What is the difference between multimodal, multi-effector, and multigenic therapies?

Multimodal therapies, also called combination therapies, utilize more than one modality of treatment such as messenger RNA, RNAi, gene therapy, and/or cell therapy. 

Multi-effector therapies utilize more than one gene effector to treat a disease, targeting complex disease states that require the action of more than one therapeutic effector on different nodes of the disease. 

​Multigenic therapies target complex diseases by using more than one transcript which encodes for two or more open reading frames and/or two or more bioactive RNA molecules. 


You can make therapies that are multimodal, multi-effector, and multigenic, or you can make therapies that fall under just one or two of these categories.