Mouse IL-36G
IL36G acts as an agonist for NF-kappa B activation through its receptor, IL1RL2, and is part of the IL-36 signaling system, which plays a role in local inflammatory responses, particularly in epithelial tissues.
Key Roles:
- Receptor Signaling: IL36G binds to the orphan receptor IL1RL2, activating NF-kappa B, which is crucial for initiating pro-inflammatory signaling pathways.
- Skin Inflammation: It is involved in skin inflammatory responses by acting on keratinocytes and dendritic cells, and indirectly influencing T-cells to promote tissue infiltration, maturation, and proliferation.
- Airway Inflammation: IL36G may play a role in pro-inflammatory responses associated with neutrophilic airway inflammation.
- Innate Immune Response: It is implicated in the innate immune response to fungal pathogens, contributing to the host defense mechanisms.
- Cytokine Production: IL36G induces bone marrow-derived dendritic cells (BMDCs) to produce several pro-inflammatory cytokines, including IL-12, IL-1β, IL-6, TNF-α, and IL-23.
- Dendritic Cell Maturation: It enhances the maturation of dendritic cells by stimulating the expression of co-stimulatory molecules such as CD80, CD86, and MHC class II.
- T-cell Activation: IL36G promotes the production of IFN-γ, IL-4, and IL-17 from cultured CD4+ T-cells and splenocytes, facilitating adaptive immune responses.
Overall, IL36G is significant in driving inflammation and immune responses, particularly in skin and airway tissues, and plays a role in both innate and adaptive immunity.
TU-1
hERP29 Proximal Promoter, a Synthetic Splice, and a portion of the hACTB gene.
A portion of the hUCP2 Proximal Promoter, a Synthetic Splice, and a terminal portion of the hS100A11 gene.
A portion of the hEIF-4A1 Proximal Promoter, a Synthetic Splice, and a terminal portion of the hADAM9 gene.
A portion of the hPCNA Proximal Promoter, a Synthetic Splice, and a terminal portion of the hCOL5A1 gene.
A portion of the Murine Cytohesin-1 Proximal Promoter, a Synthetic Splice, and a terminal portion of the hACTN1 gene.
A portion of the Mus E2A Proximal Promoter, a Synthetic Splice, and a terminal portion of the hKDELR3 gene.
A portion of the hPNP Proximal Promoter, a Synthetic Splice, and a terminal portion of the hANPEP gene.
A portion of the bMHC Proximal Promoter, a Synthetic Splice, and a terminal portion of the hCD58 gene
*NOTE: bMHC info (USPTO-US005441889A)
hERP29 Proximal Promoter, a Synthetic Splice, and a portion of the hACTB gene.
A portion of the hUCP2 Proximal Promoter, a Synthetic Splice, and a terminal portion of the hS100A11 gene.
A portion of the hEIF-4A1 Proximal Promoter, a Synthetic Splice, and a terminal portion of the hADAM9 gene.
A portion of the hPCNA Proximal Promoter, a Synthetic Splice, and a terminal portion of the hCOL5A1 gene.
A portion of the Murine Cytohesin-1 Proximal Promoter, a Synthetic Splice, and a terminal portion of the hACTN1 gene.
A portion of the Mus E2A Proximal Promoter, a Synthetic Splice, and a terminal portion of the hKDELR3 gene.
A portion of the hPNP Proximal Promoter, a Synthetic Splice, and a terminal portion of the hANPEP gene.
A portion of the bMHC Proximal Promoter, a Synthetic Splice, and a terminal portion of the hCD58 gene
*NOTE: bMHC info (USPTO-US005441889A)