Mouse IL-36B
IL36B is a pro-inflammatory cytokine involved in local inflammatory responses, particularly within epithelial tissues.
Key Roles:
- Receptor Signaling: IL36B binds to the IL1RL2/IL-36R receptor, triggering NF-kappa-B and MAPK signaling pathways, which are critical for initiating pro-inflammatory responses.
- Inflammation in Skin and Joints: It plays a significant role in skin inflammation and is also active in synovial tissues, promoting the production of interleukin-6 and interleukin-8 in synovial fibroblasts, articular chondrocytes, and adipocytes.
- Antimicrobial Peptide Production: IL36B induces the expression of antimicrobial peptides, such as beta-defensin 4 and beta-defensin 103, along with various matrix metalloproteinases, enhancing the innate immune response.
- Dendritic Cell Function: It stimulates bone marrow-derived dendritic cells (BMDCs) to produce pro-inflammatory cytokines like IL-12, IL-1β, IL-6, TNF-α, and IL-23. IL36B also activates p38 MAPK phosphorylation in these cells.
- Dendritic Cell Maturation: By promoting the surface expression of CD80, CD86, and MHC class II, IL36B enhances the maturation and function of dendritic cells.
- T-cell Activation: IL36B induces the production of IFN-γ, IL-4, and IL-17 from T-helper 1 (Th1) cells and cultured CD4+ T-cells, facilitating a robust adaptive immune response.
Overall, IL36B is integral to driving inflammation and immune responses, particularly in skin and joint tissues, and plays a role in coordinating both innate and adaptive immunity.
TU-1
hERP29 Proximal Promoter, a Synthetic Splice, and a portion of the hACTB gene.
A portion of the hUCP2 Proximal Promoter, a Synthetic Splice, and a terminal portion of the hS100A11 gene.
A portion of the hEIF-4A1 Proximal Promoter, a Synthetic Splice, and a terminal portion of the hADAM9 gene.
A portion of the hPCNA Proximal Promoter, a Synthetic Splice, and a terminal portion of the hCOL5A1 gene.
A portion of the Murine Cytohesin-1 Proximal Promoter, a Synthetic Splice, and a terminal portion of the hACTN1 gene.
A portion of the Mus E2A Proximal Promoter, a Synthetic Splice, and a terminal portion of the hKDELR3 gene.
A portion of the hPNP Proximal Promoter, a Synthetic Splice, and a terminal portion of the hANPEP gene.
A portion of the bMHC Proximal Promoter, a Synthetic Splice, and a terminal portion of the hCD58 gene
*NOTE: bMHC info (USPTO-US005441889A)
hERP29 Proximal Promoter, a Synthetic Splice, and a portion of the hACTB gene.
A portion of the hUCP2 Proximal Promoter, a Synthetic Splice, and a terminal portion of the hS100A11 gene.
A portion of the hEIF-4A1 Proximal Promoter, a Synthetic Splice, and a terminal portion of the hADAM9 gene.
A portion of the hPCNA Proximal Promoter, a Synthetic Splice, and a terminal portion of the hCOL5A1 gene.
A portion of the Murine Cytohesin-1 Proximal Promoter, a Synthetic Splice, and a terminal portion of the hACTN1 gene.
A portion of the Mus E2A Proximal Promoter, a Synthetic Splice, and a terminal portion of the hKDELR3 gene.
A portion of the hPNP Proximal Promoter, a Synthetic Splice, and a terminal portion of the hANPEP gene.
A portion of the bMHC Proximal Promoter, a Synthetic Splice, and a terminal portion of the hCD58 gene
*NOTE: bMHC info (USPTO-US005441889A)