Human IL-29
Also known as interferon lambda 1 (IFN-λ1), IL-29 is a cytokine belonging to the type III interferons group. It plays a vital role in the immune response against pathogens, particularly viruses, by targeting epithelial cells and hepatocytes, similar to type I interferons.
IL-29 has antiviral, antitumor, and immunomodulatory activities, crucial for antiviral defense, especially in epithelial tissues. It acts as a ligand for a heterodimeric receptor composed of IL10RB and IFNLR1. Engagement of this receptor activates the JAK/STAT signaling pathway, leading to the expression of interferon-stimulated genes (ISGs) that establish an antiviral state. Its receptor distribution is limited to epithelial cells, enhancing its cell-type-specific action, and it also upregulates MHC class I antigen expression, contributing to its immunomodulatory effects.
TU-1
hERP29 Proximal Promoter, a Synthetic Splice, and a portion of the hACTB gene.
A portion of the hUCP2 Proximal Promoter, a Synthetic Splice, and a terminal portion of the hS100A11 gene.
A portion of the hEIF-4A1 Proximal Promoter, a Synthetic Splice, and a terminal portion of the hADAM9 gene.
A portion of the hPCNA Proximal Promoter, a Synthetic Splice, and a terminal portion of the hCOL5A1 gene.
A portion of the Murine Cytohesin-1 Proximal Promoter, a Synthetic Splice, and a terminal portion of the hACTN1 gene.
A portion of the Mus E2A Proximal Promoter, a Synthetic Splice, and a terminal portion of the hKDELR3 gene.
A portion of the hPNP Proximal Promoter, a Synthetic Splice, and a terminal portion of the hANPEP gene.
A portion of the bMHC Proximal Promoter, a Synthetic Splice, and a terminal portion of the hCD58 gene
*NOTE: bMHC info (USPTO-US005441889A)
hERP29 Proximal Promoter, a Synthetic Splice, and a portion of the hACTB gene.
A portion of the hUCP2 Proximal Promoter, a Synthetic Splice, and a terminal portion of the hS100A11 gene.
A portion of the hEIF-4A1 Proximal Promoter, a Synthetic Splice, and a terminal portion of the hADAM9 gene.
A portion of the hPCNA Proximal Promoter, a Synthetic Splice, and a terminal portion of the hCOL5A1 gene.
A portion of the Murine Cytohesin-1 Proximal Promoter, a Synthetic Splice, and a terminal portion of the hACTN1 gene.
A portion of the Mus E2A Proximal Promoter, a Synthetic Splice, and a terminal portion of the hKDELR3 gene.
A portion of the hPNP Proximal Promoter, a Synthetic Splice, and a terminal portion of the hANPEP gene.
A portion of the bMHC Proximal Promoter, a Synthetic Splice, and a terminal portion of the hCD58 gene
*NOTE: bMHC info (USPTO-US005441889A)