Human IL-13

Interleukin 13 (IL-13), encoded by the IL13 gene, is a cytokine primarily secreted by T helper type 2 (Th2) cells, as well as other immune cells like CD4 cells, mast cells, and eosinophils. It plays a crucial role in allergic inflammation and the immune response to parasitic infections, stimulating B-cell proliferation and activating eosinophils, basophils, and mast cells. IL-13 also downregulates pro-inflammatory cytokines and antagonizes Th1-driven immune responses, partly by suppressing NF-kappa-B activity. It exerts its effects through a receptor complex composed of IL4R and IL13RA1, activating JAK1 and TYK2 to initiate the STAT6 signaling pathway, while the IL13RA2 receptor acts as a high-affinity decoy, internalizing and depleting extracellular IL-13.

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Product number: SW10064.1

TU-1

hERP29 Proximal Promoter, a Synthetic Splice, and a portion of the hACTB gene.

A portion of the hUCP2 Proximal Promoter, a Synthetic Splice, and a terminal portion of the hS100A11 gene.

A portion of the hEIF-4A1 Proximal Promoter, a Synthetic Splice, and a terminal portion of the hADAM9 gene.

A portion of the hPCNA Proximal Promoter, a Synthetic Splice, and a terminal portion of the hCOL5A1 gene.

A portion of the Murine Cytohesin-1 Proximal Promoter, a Synthetic Splice, and a terminal portion of the hACTN1 gene.

A portion of the Mus E2A Proximal Promoter, a Synthetic Splice, and a terminal portion of the hKDELR3 gene.

A portion of the hPNP Proximal Promoter, a Synthetic Splice, and a terminal portion of the hANPEP gene.

A portion of the bMHC Proximal Promoter, a Synthetic Splice, and a terminal portion of the hCD58 gene

*NOTE: bMHC info (USPTO-US005441889A)